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Maria Krutikov

University College London / Brighton & Sussex Medical School


Maria Krutikov

Maria currently holds a Clinical Lecturer position at Institute of Health Informatics (IHI) and is mainly working within the VIVALDI Social Care study, the largest infection research database of care homes in England, led by Professor Laura Shallcross. This dataset will be used to describe the epidemiology of infections and antimicrobial resistance in this under-researched population and consider interventions to limit infection spread, in preparation for future infectious threats.

Maria successfully completed her Wellcome Trust funded clinical PhD in infectious disease epidemiology at the UCL Institute of Health Informatics in 2023. Her PhD described the epidemiological burden of SARS-CoV-2 infection in care homes in England and identified facility-level factors associated with infections and outbreaks. This work was delivered using a mixture of serological sampling, data linkage to large routine health datasets, and surveys of the built environment. This was hosted in the VIVALDI study, a government-funded core COVID-19 surveillance study of English care homes that was hosted by UCL. Maria played a key role in setting up and running this study, which was based in ~330 care homes for older people. Maria is first author on ten peer-reviewed publications associated with this study and is co-author on fifteen more.

Maria studied medicine at the University of Manchester and subsequently undertook medical rotations at the Manchester Royal Infirmary, University College Hospitals London and Barts Health NHS Trust in East London. She currently holds a specialty registrar training number in Infectious Diseases & Medical Microbiology and is working clinically at the University Hospitals Sussex NHS Trust. She has combined clinical training with academic training and has gained a distinction in a Masters degree in Applied Infectious Disease Epidemiology at UCL.

She has also worked on research projects both nationally and internationally, including an ECDC-funded mixed-methods study in Riga, Latvia focussing on interventions to improve adherence to TB treatment, as well as leading a systematic review commissioned by FIND in Russian and English on TB skin tests, which informed WHO TB screening guidelines and was published in Lancet ID.

FURTHER INFORMATION

Countries United Kingdom;
Topics Co-production in LTC; COVID-19 and other infectious diseases and LTC; Epidemiology and ageing trajectories; Healthcare access in LTC; Information and data systems in LTC;
Methods Co-production methods; Implementation science; Literature reviews and synthesis; Longitudinal data analysis; Mixed methods; Observational studies; Quantitative data analysis; Translation and cultural adaptation of instruments;
Role Research;
Interest Groups Data Science; Quality improvement in Long-Term Care; Quasi-experimental methods; Technology and Long-Term Care; Unmet need inequalities and care poverty (UNICAP);
Websitehttps://profiles.ucl.ac.uk/72199-maria-krutikov/about
ORC.ID0000-0002-3982-642X
GOOGLE SCHOLARhttps://scholar.google.co.uk/citations?hl=en&user=Ib7xTHkAAAAJ
Research interests

Infectious Disease Epidemiology
Data linkage & Electronic Health Records
Care homes for older people
Tuberculosis
Infections in underserved populations
infection Prevention & Control
Antimicrobial Resistance

Key publications
  1. Krutikov M, Fry Z, Azmi B et al. Protocol for VIVALDI Social Care: Pilot Study to reduce Infections, Outbreaks and Antimicrobial Resistance in Care Homes for Older Adults. NIHR Open Res 2024; 4:4. doi:org/10.3310/nihropenres.13530.1
  2. Krutikov M, Stirrup O, Azmi B et al. Built environment and SARS-CoV-2 Transmission in Long-Term Care Facilities: Cross-Sectional Survey and Data Linkage. JAMDA 2024; 25(2): 304-313.E11. doi:10.1016/j.jamda.2023.10.027
  3. Krutikov M, Faust L, Nikolayevskky V et al. The diagnostic performance of novel skin-based in vivo tests for tuberculosis infection compared to PPD Tuberculin skin tests and blood-based in vitro interferon-gamma release assays: A systematic review and meta-analysis. Lancet Infectious Diseases 2022;22(2):250-264. doi:10.1016/S1473-3099(21)00261-9
  4. Krutikov M, Stirrup O, Nacer-Laidi H et al. Outcomes of SARS-CoV-2 Omicron infection in residents of Long-Term Care. Lancet Healthy Longev 2022; 3(5):e347-e355. doi: 10.1016/S2666-7568(22)00093-9
  5. Krutikov M, Palmer T, Tut G et al. Prevalence and duration of detectable SARS-CoV-2 nucleocapsid antibodies in staff and residents of long-term care facilities over the first year of the pandemic (WIVALDI study): prospective cohort study in England. Lancet Healthy Longevity 2022;3:e13-21. doi:10.1016/S2666-7568(21)00282-8
  6. Krutikov M, Hayward A, Shallcross S. Spread of a variant SARS-CoV-2 in long term care facilities in England. N Engl J Med 2021; 384:1671-1673. doi:10.1056/NEJMc2035906
  7. Shrotri M, Krutikov M, Palmer T. et al. Vaccine effectiveness of the first dose of ChAdOx1 nCoV-19 and BNT162b2 against SARS-CoV-2 infection in residents of Long-Term Care Facilities (VIVALDI study). Lancet infectious Diseases 2021; doi:1101/2021.03.26.21254391
  8. Gupta RK, Calderwood C, Yavlinsky A, Krutikov M et al. Discovery and validation of a personalized risk predictor for incident tuberculosis in settings with low transmission. Nature Medicine 2020;26, 1941–1949. org/10.1038/s41591-020-1076-0
  9. Krutikov M, Bruchfeld J, Migliori G, Borisov S, Tiberi S. 2018. ERS Monograph Edition 82 – Tuberculosis. Chapter 11: New and repurposed drugs. Sheffield: ERS publications
  10. Krutikov M, Donovan J, Lambourne J, et al. The Development and Evaluation of a Combined Infection-Rheumatology Assessment Service in Response to the Chikungunya Fever Epidemic. Am J Trop Med Hyg 2023; 108(5): 1003-1006. doi:10.4269/ajtmh.22-0698